K.Leung Group
Undergraduate student
Corresponding author*
J. Morse, D. Wang, S. Mei, D. Whitham, C. Hladun, C. C. Darie, H. O Sintim*, M. Wang*, K. Leung*
"Chloride Homeostasis Regulates cGAS-STING Signaling." BioRxiv, 2024, DOI:10.1101/2024.04.08.588475
J. Morse†, N. Ofodum†, F.K. Tang†, M. Schmidt, X. Lu*, K. Leung*
"Leveraging Metal Complexes for Microsecond Lifetime-Based Chloride Sensing." ACS Sensors. 2025, DOI:10.1021/acssensors.4c03195
"FRET-based reporter assesses lysosomal DNA-degradation ability in live cells" Sensors and Actuators Reports, 2025, 9, 100259
A. S. Deshpande, T. Bechard, E. DeVoe, J. Morse, R. Khan, K. Leung, S. Andreescu*
"Real-time monitoring of cellular superoxide anion release in THP-1 cells using a catalytically amplified superoxide dismutase–based microbiosensor" Analytical and Bioanalytical Chemistry, 2024, 416, 4727
P. Gupta, K. Chaudagar, S. Sharma-Saha, K. Bynoe, L. Maillat, B. Heiss, K. Leung, Y. Krishnan, W. Stadler, A. Patnaik*
"PARP/PI3K inhibitor combination therapy eradicates c-MYC-driven murine prostate cancers via cGAS/STING pathway activation within tumor-associated macrophages" Cancer Res, 2021, DOI:10.1158/1538-7445.AM2021-1685
2016-2020
K.H. Leung, K. Chakraborty, A. Saminathan, Y. Krishnan*, “A DNA Nanomachine chemically resolves lysosomes in live cells.” Nature Nanotechnology, 2019, 14, 176.
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Editorial, “DNA nanostructures fingerprint cellular organelles” Nature Nanotechnology, 2019, 14, 99.
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“Researchers use DNA nanomachines to discover subgroups of lysosomes” Phys.org
N. Narayanaswamy, K. Chakraborty, A. Saminathan, E. Zeichner, K. Leung, J. Devany, Y. Krishnan* "A pH-correctable, DNA-based fluorescent reporter for organellar Calcium.” Nature Methods, 2019, 16, 95.
Highlighted in:
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Editorial, “DNA nanostructures fingerprint cellular organelles” Nature Nanotechnology, 2019, 14, 99.
K. Leung, Y. Krishnan*, “Dynamic RNA Nanotechnology Enters the CRISPR Toolbox.” ACS Central Science, 2019, 5, 1111.
2011-2015
Bioactive transition‐metal complexes for biomedical applications
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G-quadruplex recognition for DNA nanosensor
X. Lin, K.-H. Leung (Co-first author), L. Lin, L. Lin, S. Lin, C.-H. Leung, D.-L. Ma*, J.-M. Lin*. “Determination of cell metabolite VEGF165 and dynamic analysis of protein-DNA interactions by combination of microfluidic technique and luminescent switch-on probe” Biosens. Bioelectron., 2016, 79, 25.
K.-H. Leung, H.-Z. He, B. He, H.-J. Zhong, S. Lin, Y.-T Wang, D.-L. Ma*, C.-H. Leung*. “Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe” Chem. Sci., 2015, 6, 2166
K.-H. Leung, B. He, C. Yang, C.-H. Leung*, H.-M. D. Wang*, D.-L. Ma*. “Development of an aptamer-based sensing platform for metal ions, proteins and small molecules through terminal deoxynucleotidyl transferase-induced G-quadruplex formation” ACS Appl. Mater. Interfaces, 2015, 7, 24046
H.-Z. He, K.-H. Leung, W. Wang, D. S.-H. Chan, C.-H. Leung, D.-L. Ma*. “Label-free luminescence switch-on detection of T4 polynucleotide kinase activity using a G-quadruplex-selective probe” Chem. Commun., 2014, 50, 5313.
D.-L. Ma*, S. Lin, K.-H. Leung, H.-J. Zhong, L.-J. Liu, D. S.-H. Chan, A. Bourdoncle, J.-L. Mergny, H.-M. D. Wang*, C.-H. Leung*. “An oligonucleotide-based label-free luminescent switch-on probe for RNA detection utilizing a G-quadruplex-selective iridium(III) complex” Nanoscale, 2014, 6, 8489.
M. Wang, K.-H. Leung (Co-first author), S. Lin, D. S.-H. Chan, D.W.J. Kwong*, C.-H. Leung*, D.-L. Ma* “A colorimetric chemosensor for Cu2+ ion detection based on an iridium(III) complex” Sci. Rep., 2014, 4, 6794.
M. Wang, K.-H. Leung (Co-first author), S. Lin, D. S.-H. Chan, C.-H. Leung, D.-L. Ma*. “A G-quadruplex-based, label-free, switch-on luminescent detection assay for Ag+ ions based on the exonuclease III-mediated digestion of C-Ag+-C DNA” J. Mater. Chem. B, 2014, 2, 6467.
K.-H. Leung, H.-Z. He, V. P.-Y. Ma, H.-J. Zhong, D. S.-H. Chan, J. Zhou, J.-L. Mergny, C.-H. Leung*, D.-L. Ma*. “Detection of base excision repair enzyme activity using a luminescent G-quadruplex selective switch-on probe” Chem. Commun., 2013, 49, 5630.
K.-H. Leung, H.-Z. He, V. P.-Y. Ma, D. S.-H. Chan, C.-H. Leung*, D.-L. Ma*. “A luminescent G-quadruplex switch-on probe for the highly selective and tunable detection of cysteine and glutathione” Chem. Commun., 2013, 49, 771.
K.-H. Leung, H.-Z. He, W. Wang, H.-J. Zhong, D. S.-H. Chan, C.-H. Leung*, D.-L. Ma*. “Label-free luminescent switch-on detection of endonuclease IV activity using a G-quadruplex-selective iridium(III) complex” ACS Appl. Mater. Interfaces, 2013, 23, 12249.
K.-H. Leung, H.-Z. He, H. Yang, D. S.-H. Chan, C.-H. Leung*, D.-L. Ma*. “A G-quadruplex-selective luminescent switch-on probe for the detection of sub-nanomolar human neutrophil elastase” RSC Adv., 2013, 3, 1656.
K.-H. Leung, H.-Z. He, D. S.-H. Chan, W.-C. Fu, C.-H. Leung, D.-L. Ma*. “An oligonucleotide-based switch-on luminescent probe for the detection of kanamycin in aqueous solution” Sensor Actuat. B-Chem., 2013, 177, 487.
K.-H. Leung, H.-Z. He, H.-J. Zhong, L. Lu, D. S.-H. Chan, D.-L. Ma*, C.-H. Leung*. “A highly sensitive G-quadruplex-based luminescent switch-on probe for the detection of polymerase 3' to 5' proofreading activity” Methods, 2013, 64, 224.
H.-Z. He, K.-H. Leung, H. Yang, D. S.-H. Chan, C.-H. Leung, J. Zhou, A. Bourdoncle, J.-L. Mergny, D.-L. Ma*. "Label-free detection of picomolar lead(II) ions in aqueous solution using a metal-based luminescent switch-on probe" Biosens. Bioelectron., 2013, 41, 871.
K.-H. Leung, L. Lu, M. Wang, T.-Y. Mak, D. S.-H. Chan, F.-K. Tang, C.-H. Leung, H.-Y. Kwan, Z. Yu, D.-L. Ma*. “A label-free luminescent switch-on assay for ATP using a G-quadruplex-selective iridium(III) complex” PLoS ONE, 2013, 10, e77921.
D.-L. Ma*, H.-Z. He, K.-H. Leung, H.-J. Zhong, D. S.-H. Chan, C.-H. Leung*. “Label-free luminescent DNA oligonucleotide-based probes” Chem. Soc. Rev., 2013, 42, 3427.
K.-H. Leung, V. P.-Y. Ma, H.-Z. He, D. S.-H. Chan, C.-H. Leung, D.-L. Ma*. "A highly selective G-quadruplex-based luminescent switch-on probe for the detection of nanomolar strontium(II) ion in sea water" RSC Adv., 2012, 2, 8273.
H.-Z. He, K.-H. Leung (Co-first author), W.-C. Fu, D. S.-H. Chan, C.-H. Leung, D.-L. Ma*. “Application of a DNA-based luminescence switch-on method for the detection of mercury(II) ions in water samples of Hong Kong” Environ. Res. Lett., 2012, 7, 044032.
Highlighted in
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Environmental research web - Insight: mercury sensing by a label-free DNA-based biosensor, Feb 11, 2013
H.-Z. He, V. P.-Y. Ma, K.-H. Leung (Co-first author), D. S.-H. Chan, H. Yang, Z. Cheng, C.-H. Leung, D.-L. Ma*. "A label-free G-quadruplex-based switch-on fluorescence assay for the selective detection of ATP" Analyst, 2012, 137, 1538.
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Vibhuti Patel, Deputy Editor of Analyst
D.-L. Ma*, H.-Z. He, V. P.-Y. Ma, D. S.-H. Chan, K.-H. Leung, H.-J. Zhong, L.-H. Lu, J.-L. Mergny, C.-H. Leung. "Label-free sensing of pH and silver nanoparticles using an "OR" logic gate" Anal. Chim. Acta, 2012, 733, 78.
D.-L. Ma*, V. P.-Y. Ma, D. S.-H. Chan, H.-Z. He, K.-H. Leung, C.-H. Leung*. "Recent advances in luminescent metal complexes for sensing" Coord. Chem. Rev., 2012, 256, 3087.
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Structure-based inhibitors
C.-H. Leung*, L.-J. Liu, K.-H. Leung, D.-L. Ma*. “Epigenetic modulation by inorganic metal complexes” Coord. Chem. Rev., 2016, 319, 25.
H.-J. Zhong, L. Lu, K.-H. Leung, C. C. L. Wong, C. Peng, S.-C. Yan, D.-L. Ma, * Z. Cai*, H.-M. D.Wang*, C. H. Leung* “An iridium(III) based irreversible protein–protein interaction inhibitor of BRD4 as a potent anticancer agent” Chem. Sci., 2015, 6, 5400
K.-H. Leung, L.-J. Liu, S. Lin, L. Lu, H.-J. Zhong, D. Susanti, W. Rao, M. Wang, W.-I. Che, D. S.-H. Chan, C.-H. Leung*, P. W.-H. Chan*, D.-L. Ma*. “Discovery of a Small-Molecule Inhibitor of STAT3 by Ligand-Based Pharmacophore Screening” Methods, 2015, 71, 38.
H.-J. Zhong, K.-H. Leung (Co-first author), S. Lin, D. S.-H. Chan, Q.-B. Han, S. L.-F. Chan, D.-L. Ma*, C.-H. Leung*. “Discovery of Deoxyvasicinone Derivatives as Inhibitors of NEDD8-Activating Enzyme” Methods, 2015, 71, 71.
L.-J. Liu, K.-H. Leung, S. Lin, D. S.-H. Chan, D. Susanti, W. Rao, P. W. H. Chan, D.-L. Ma*, C.-H. Leung*. “Pharmacophore modeling for the identification of small-molecule inhibitors of TACE” Methods, 2015, 71, 92.
D.-L. Ma*, L.-J. Liu, K.-H. Leung, Y.-T. Chen, H.-J. Zhong, D. S.-H. Chan, H.-M. D. Wang*, C.-H. Leung*. “Antagonising STAT3 dimerization by a rhodium(III) complex” Angew. Chem. Int. Ed., 2014, 53, 9178.
L.-J. Liu, K.-H. Leung (Co-first author), D. S.-H. Chan, D.-L. Ma*, C.-H. Leung*. “Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening” Cell Death Dis., 2014, 5, e1293.
H.-J. Zhong, K.-H. Leung (Co-first author), L.-J. Liu, L. Lu, D. S.-H. Chan, C.-H. Leung*, D.-L. Ma*. “Antagonism of mTOR Activity by a kinetically inert rhodium(III) complex” ChemPlusChem, 2014, 79, 508.
H. Yang, H.-J. Zhong, K.-H. Leung (Co-first author), D. S.-H. Chan, V. P.-Y. Ma, R. Nanjunda, W. D. Wilson, D.-L. Ma*, C.-H. Leung*. “Structure-Based Design of Flavone Derivatives as c-myc Oncogene Down-Regulators” Eur. J. Pharm. Sci., 2013, 48, 130.
D.-L. Ma*, V. P.-Y. Ma, D. S.-H. Chan, K.-H. Leung, H.-Z. He, C.-H. Leung*. “Bioactive luminescent transition‐metal complexes for biomedical applications” Angew. Chem., Int. Ed., 2013, 52, 7666.
H.-J. Zhong, V. P.-Y. Ma, Z. Cheng, D. S.-H. Chan, H.-Z. He, K.-H. Leung, D.-L. Ma*, C.-H. Leung*. "Discovery of a Natural Product Inhibitor Targeting Protein Neddylation by Structure-Based Virtual Screening" Biochimie, 2012, 94, 2457.
D.-L. Ma*, D. S.-H. Chan, V. P.-Y. Ma, K.-H. Leung, H.-J. Zhong, C.-H. Leung*. "Current advancements in Ab luminescent probes and inhibitors of Ab aggregation" Curr. Alzheimer Res., 2012, 9, 830.
D.-L. Ma*, V. P.-Y. Ma, D. S.-H. Chan, K.-H. Leung, H.-J. Zhong, C.-H. Leung*. "In silico screening of quadruplex-binding ligands" Methods, 2012, 57, 106.
D.-L. Ma*, V. P.-Y. Ma, D. S.-H. Chan, H.-Z. He, K.-H. Leung, C.-H. Leung*. "Recent advances in luminescent metal complexes for sensing" Coord. Chem. Rev., 2012, 256, 3087.
