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44. J. Morse†, N. Ofodum†, F.K. Tang†, M. Schmidt, X. Lu*, K. Leung* 

Leveraging Metal Complexes for Microsecond Lifetime-Based Chloride Sensing

ChemRxiv. 2024, 10.26434/chemrxiv-2024-ncn19
ACS Sensors. 2025, 10, 2, 657–663 (link)​​

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43. J. Morse, K. Leung* 

FRET-based reporter assesses lysosomal DNA-degradation ability in live cells

Sensors and Actuators Reports, 2025, 9, 100259

42. A. S. Deshpande, T. Bechard, E. DeVoe, J. Morse, R. Khan, K. Leung, S. Andreescu*

Real-time monitoring of cellular superoxide anion release in THP-1 cells using a catalytically amplified superoxide dismutase–based microbiosensor

Analytical and Bioanalytical Chemistry, 2024, 416, 4727. (link)​

41. P. Gupta, K. Chaudagar, S. Sharma-Saha, K. Bynoe, L. Maillat, B. Heiss, K. Leung, Y. Krishnan, W. Stadler, A. Patnaik*

PARP/PI3K inhibitor combination therapy eradicates c-MYC-driven murine prostate cancers via cGAS/STING pathway activation within tumor-associated macrophages

Cancer Res,  2021, DOI:10.1158/1538-7445.AM2021-1685​

40. J. Osei-Owusu, J. Yang, K. Leung, Z. Ruan, W. Lu, Y. Krishnan and Z. Qiu*

Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis.

Cell Reports, 2021, 34, 108683. (link)

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2016-2020​​​​​​​​​​​​

39. K. Leung, K. Chakraborty, A. Saminathan, Y. Krishnan*

A DNA Nanomachine chemically resolves lysosomes in live cells

Nature Nanotechnology, 2019, 14, 176. (link)

​

Highlighted in:

  • C.-M. Horejs (Associate Editor of Nature Reviews Materials), “Lysosomes uncovered” Nature Reviews Materials, 2019, 4, 2.

  • Editorial, “DNA nanostructures fingerprint cellular organelles” Nature Nanotechnology, 2019, 14, 99.

  • “Researchers use DNA nanomachines to discover subgroups of lysosomes” Phys.org 

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38. N. Narayanaswamy, K. Chakraborty, A. Saminathan, E. Zeichner, K. Leung, J. Devany, Y. Krishnan*

A pH-correctable, DNA-based fluorescent reporter for organellar Calcium.

Nature Methods, 2019, 16, 95. ​(link)

 

Highlighted in:

Editorial, “DNA nanostructures fingerprint cellular organelles” Nature Nanotechnology, 2019, 14, 99.​

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​36. K. Chakraborty, K. Leung, Y. Krishnan*

High lumenal chloride in the lysosome is critical for lysosome function 

eLIFE, 2017, 6, e28862. (link)

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2011-2015 

Bioactive transition‐metal complexes for biomedical applications​

a. G-quadruplex recognition for DNA nanosensor​​​​​​

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33. K.-H. Leung, B. He, C. Yang, C.-H. Leung*, H.-M. D. Wang*, D.-L. Ma*

Development of an aptamer-based sensing platform for metal ions, proteins and small molecules through terminal deoxynucleotidyl transferase-induced G-quadruplex formation

ACS Appl. Mater. Interfaces, 2015, 7, 24046 

32. H.-Z. He, K.-H. Leung, W. Wang, D. S.-H. Chan, C.-H. Leung, D.-L. Ma*

Label-free luminescence switch-on detection of T4 polynucleotide kinase activity using a G-quadruplex-selective probe

Chem. Commun., 2014, 50, 5313

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31. D.-L. Ma*, S. Lin, K.-H. Leung, H.-J. Zhong, L.-J. Liu, D. S.-H. Chan, A. Bourdoncle, J.-L. Mergny, H.-M. D. Wang*, C.-H. Leung*

An oligonucleotide-based label-free luminescent switch-on probe for RNA detection utilizing a G-quadruplex-selective iridium(III) complex

Nanoscale, 2014, 6, 8489

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30. M. Wang, K.-H. Leung (Co-first author), S. Lin, D. S.-H. Chan, D.W.J. Kwong*, C.-H. Leung*, D.-L. Ma*

A colorimetric chemosensor for Cu2+ ion detection based on an iridium(III) complex

Sci. Rep., 2014, 4, 6794

29. M. Wang, K.-H. Leung (Co-first author), S. Lin, D. S.-H. Chan, C.-H. Leung, D.-L. Ma*

A G-quadruplex-based, label-free, switch-on luminescent detection assay for Ag+ ions based on the exonuclease III-mediated digestion of C-Ag+-C DNA

J. Mater. Chem. B, 2014, 2, 6467

28. K.-H. Leung, H.-Z. He, V. P.-Y. Ma, H.-J. Zhong, D. S.-H. Chan, J. Zhou, J.-L. Mergny, C.-H. Leung*, D.-L. Ma*

Detection of base excision repair enzyme activity using a luminescent G-quadruplex selective switch-on probe

Chem. Commun., 2013, 49, 5630

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27. K.-H. Leung, H.-Z. He, V. P.-Y. Ma, D. S.-H. Chan, C.-H. Leung*, D.-L. Ma*

A luminescent G-quadruplex switch-on probe for the highly selective and tunable detection of cysteine and glutathione

Chem. Commun., 2013, 49, 771

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26. K.-H. Leung, H.-Z. He, W. Wang, H.-J. Zhong, D. S.-H. Chan, C.-H. Leung*, D.-L. Ma*

Label-free luminescent switch-on detection of endonuclease IV activity using a G-quadruplex-selective iridium(III) complex

ACS Appl. Mater. Interfaces, 2013, 23, 12249

25. K.-H. Leung, H.-Z. He, H. Yang, D. S.-H. Chan, C.-H. Leung*, D.-L. Ma*

A G-quadruplex-selective luminescent switch-on probe for the detection of sub-nanomolar human neutrophil elastase

RSC Adv., 2013, 3, 1656

24. K.-H. Leung, H.-Z. He, D. S.-H. Chan, W.-C. Fu, C.-H. Leung, D.-L. Ma*

An oligonucleotide-based switch-on luminescent probe for the detection of kanamycin in aqueous solution

Sensor Actuat. B-Chem., 2013, 177, 487

23. K.-H. Leung, H.-Z. He, H.-J. Zhong, L. Lu, D. S.-H. Chan, D.-L. Ma*, C.-H. Leung*

A highly sensitive G-quadruplex-based luminescent switch-on probe for the detection of polymerase 3' to 5' proofreading activity

Methods, 2013, 64, 224. 

22. H.-Z. He, K.-H. Leung, H. Yang, D. S.-H. Chan, C.-H. Leung, J. Zhou, A. Bourdoncle, J.-L. Mergny, D.-L. Ma*

Label-free detection of picomolar lead(II) ions in aqueous solution using a metal-based luminescent switch-on probe

Biosens. Bioelectron., 2013, 41, 871.

21. K.-H. Leung, L. Lu, M. Wang, T.-Y. Mak, D. S.-H. Chan, F.-K. Tang, C.-H. Leung, H.-Y. Kwan, Z. Yu, D.-L. Ma*

A label-free luminescent switch-on assay for ATP using a G-quadruplex-selective iridium(III) complex

PLoS ONE, 2013, 10, e77921. 

20. D.-L. Ma*, H.-Z. He, K.-H. Leung, H.-J. Zhong, D. S.-H. Chan, C.-H. Leung*

Label-free luminescent DNA oligonucleotide-based probes

Chem. Soc. Rev., 2013, 42, 3427

19. K.-H. Leung, V. P.-Y. Ma, H.-Z. He, D. S.-H. Chan, C.-H. Leung, D.-L. Ma*

A highly selective G-quadruplex-based luminescent switch-on probe for the detection of nanomolar strontium(II) ion in sea water

RSC Adv., 2012, 2, 8273

18. H.-Z. He, K.-H. Leung (Co-first author), W.-C. Fu, D. S.-H. Chan, C.-H. Leung, D.-L. Ma*

Application of a DNA-based luminescence switch-on method for the detection of mercury(II) ions in water samples of Hong Kong

Environ. Res. Lett., 2012, 7, 044032

 

Highlighted in

  • Environmental research web - Insight: mercury sensing by a label-free DNA-based biosensor, Feb 11, 2013

17. H.-Z. He, V. P.-Y. Ma, K.-H. Leung (Co-first author), D. S.-H. Chan, H. Yang, Z. Cheng, C.-H. Leung, D.-L. Ma*

A label-free G-quadruplex-based switch-on fluorescence assay for the selective detection of ATP

Analyst, 2012, 137, 1538

 

Highlighted in

16. D.-L. Ma*, H.-Z. He, V. P.-Y. Ma, D. S.-H. Chan, K.-H. Leung, H.-J. Zhong, L.-H. Lu, J.-L. Mergny, C.-H. Leung

Label-free sensing of pH and silver nanoparticles using an "OR" logic gate

Anal. Chim. Acta, 2012, 733, 78

15. D.-L. Ma*, V. P.-Y. Ma, D. S.-H. Chan, H.-Z. He, K.-H. Leung, C.-H. Leung*

Recent advances in luminescent metal complexes for sensing

Coord. Chem. Rev., 2012, 256, 3087

Bioactive transition‐metal complexes for biomedical applications​

b. Structure-based inhibitor​s 

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14. C.-H. Leung*, L.-J. Liu, K.-H. Leung, D.-L. Ma*

Epigenetic modulation by inorganic metal complexes

Coord. Chem. Rev., 2016, 319, 2

13. H.-J. Zhong, L. Lu, K.-H. Leung, C. C. L. Wong, C. Peng, S.-C. Yan, D.-L. Ma, * Z. Cai*, H.-M. D.Wang*, C. H. Leung*

An iridium(III) based irreversible protein–protein interaction inhibitor of BRD4 as a potent anticancer agent

Chem. Sci., 2015, 6, 5400

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12. K.-H. Leung, L.-J. Liu, S. Lin, L. Lu, H.-J. Zhong, D. Susanti, W. Rao, M. Wang, W.-I. Che, D. S.-H. Chan, C.-H. Leung*, P. W.-H. Chan*, D.-L. Ma*

Discovery of a Small-Molecule Inhibitor of STAT3 by Ligand-Based Pharmacophore Screening

Methods, 2015, 71, 38

11. H.-J. Zhong, K.-H. Leung (Co-first author), S. Lin, D. S.-H. Chan, Q.-B. Han, S. L.-F. Chan, D.-L. Ma*, C.-H. Leung*

Discovery of Deoxyvasicinone Derivatives as Inhibitors of NEDD8-Activating Enzyme

Methods, 2015, 71, 71

10. L.-J. Liu, K.-H. Leung, S. Lin, D. S.-H. Chan, D. Susanti, W. Rao, P. W. H. Chan, D.-L. Ma*, C.-H. Leung*

Pharmacophore modeling for the identification of small-molecule inhibitors of TACE

Methods, 2015, 71, 92

9. D.-L. Ma*, L.-J. Liu, K.-H. Leung, Y.-T. Chen, H.-J. Zhong, D. S.-H. Chan, H.-M. D. Wang*, C.-H. Leung*

Antagonising STAT3 dimerization by a rhodium(III) complex

Angew. Chem. Int. Ed., 2014, 53, 9178

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8. L.-J. Liu, K.-H. Leung (Co-first author), D. S.-H. Chan, D.-L. Ma*, C.-H. Leung*

Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening

Cell Death Dis., 2014, 5, e1293.

7. H.-J. Zhong, K.-H. Leung (Co-first author), L.-J. Liu, L. Lu, D. S.-H. Chan, C.-H. Leung*, D.-L. Ma*

“Antagonism of mTOR Activity by a kinetically inert rhodium(III) complex

ChemPlusChem, 2014, 79, 508

6. H. Yang, H.-J. Zhong, K.-H. Leung (Co-first author), D. S.-H. Chan, V. P.-Y. Ma, R. Nanjunda, W. D. Wilson, D.-L. Ma*, C.-H. Leung*

Structure-Based Design of Flavone Derivatives as c-myc Oncogene Down-Regulators

Eur. J. Pharm. Sci., 2013, 48, 130

5. D.-L. Ma*, V. P.-Y. Ma, D. S.-H. Chan, K.-H. Leung, H.-Z. He, C.-H. Leung*

Bioactive luminescent transition‐metal complexes for biomedical applications

Angew. Chem., Int. Ed., 2013, 52, 7666

4. H.-J. Zhong, V. P.-Y. Ma, Z. Cheng, D. S.-H. Chan, H.-Z. He, K.-H. Leung, D.-L. Ma*, C.-H. Leung*

Discovery of a Natural Product Inhibitor Targeting Protein Neddylation by Structure-Based Virtual Screening

Biochimie, 2012, 94, 2457

3. D.-L. Ma*, D. S.-H. Chan, V. P.-Y. Ma, K.-H. Leung, H.-J. Zhong, C.-H. Leung*

Current advancements in Ab luminescent probes and inhibitors of Ab aggregation

Curr. Alzheimer Res., 2012, 9, 830. 

2. D.-L. Ma*, V. P.-Y. Ma, D. S.-H. Chan, K.-H. Leung, H.-J. Zhong, C.-H. Leung*

In silico screening of quadruplex-binding ligands

Methods, 2012, 57, 106

1. D.-L. Ma*, V. P.-Y. Ma, D. S.-H. Chan, H.-Z. He, K.-H. Leung, C.-H. Leung*

Recent advances in luminescent metal complexes for sensing

Coord. Chem. Rev., 2012, 256, 3087

© KLeung Research Group

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