K.Leung Group
Undergraduate student
Corresponding author*
J. Morse, D. Wang, S. Mei, D. Whitham, C. Hladun, C. C. Darie, H. O Sintim*, M. Wang*, K. Leung*
Chloride Homeostasis Regulates STING Signaling
BioRxiv, 2024, DOI:10.1101/2024.04.08.588475
J. Morse†, M. R. Nadiveedhi†, M. Schmidt, F.K. Tang, C. Hladun, P. Ganesh, Z. Qiu, K. Leung*
Tunable Cytosolic Chloride Indicators for Real-Time Chloride Imaging in Live Cells.
44. J. Morse†, N. Ofodum†, F.K. Tang†, M. Schmidt, X. Lu*, K. Leung*
Leveraging Metal Complexes for Microsecond Lifetime-Based Chloride Sensing
ChemRxiv. 2024, 10.26434/chemrxiv-2024-ncn19
ACS Sensors. 2025, 10, 2, 657–663
FRET-based reporter assesses lysosomal DNA-degradation ability in live cells
Sensors and Actuators Reports, 2025, 9, 100259
42. A. S. Deshpande, T. Bechard, E. DeVoe, J. Morse, R. Khan, K. Leung, S. Andreescu*
Real-time monitoring of cellular superoxide anion release in THP-1 cells using a catalytically amplified superoxide dismutase–based microbiosensor
41. P. Gupta, K. Chaudagar, S. Sharma-Saha, K. Bynoe, L. Maillat, B. Heiss, K. Leung, Y. Krishnan, W. Stadler, A. Patnaik*
PARP/PI3K inhibitor combination therapy eradicates c-MYC-driven murine prostate cancers via cGAS/STING pathway activation within tumor-associated macrophages
2016-2020
39. K. Leung, K. Chakraborty, A. Saminathan, Y. Krishnan*
A DNA Nanomachine chemically resolves lysosomes in live cells
Nature Nanotechnology, 2019, 14, 176.
Highlighted in:
2011-2015
Bioactive transition‐metal complexes for biomedical applications
a. G-quadruplex recognition for DNA nanosensor
33. K.-H. Leung, B. He, C. Yang, C.-H. Leung*, H.-M. D. Wang*, D.-L. Ma*
Development of an aptamer-based sensing platform for metal ions, proteins and small molecules through terminal deoxynucleotidyl transferase-induced G-quadruplex formation
ACS Appl. Mater. Interfaces, 2015, 7, 24046
32. H.-Z. He, K.-H. Leung, W. Wang, D. S.-H. Chan, C.-H. Leung, D.-L. Ma*
Label-free luminescence switch-on detection of T4 polynucleotide kinase activity using a G-quadruplex-selective probe
Chem. Commun., 2014, 50, 5313
31. D.-L. Ma*, S. Lin, K.-H. Leung, H.-J. Zhong, L.-J. Liu, D. S.-H. Chan, A. Bourdoncle, J.-L. Mergny, H.-M. D. Wang*, C.-H. Leung*
An oligonucleotide-based label-free luminescent switch-on probe for RNA detection utilizing a G-quadruplex-selective iridium(III) complex
Nanoscale, 2014, 6, 8489
30. M. Wang, K.-H. Leung (Co-first author), S. Lin, D. S.-H. Chan, D.W.J. Kwong*, C.-H. Leung*, D.-L. Ma*
A colorimetric chemosensor for Cu2+ ion detection based on an iridium(III) complex
Sci. Rep., 2014, 4, 6794
29. M. Wang, K.-H. Leung (Co-first author), S. Lin, D. S.-H. Chan, C.-H. Leung, D.-L. Ma*
A G-quadruplex-based, label-free, switch-on luminescent detection assay for Ag+ ions based on the exonuclease III-mediated digestion of C-Ag+-C DNA
J. Mater. Chem. B, 2014, 2, 6467
28. K.-H. Leung, H.-Z. He, V. P.-Y. Ma, H.-J. Zhong, D. S.-H. Chan, J. Zhou, J.-L. Mergny, C.-H. Leung*, D.-L. Ma*
Detection of base excision repair enzyme activity using a luminescent G-quadruplex selective switch-on probe
Chem. Commun., 2013, 49, 5630
27. K.-H. Leung, H.-Z. He, V. P.-Y. Ma, D. S.-H. Chan, C.-H. Leung*, D.-L. Ma*
A luminescent G-quadruplex switch-on probe for the highly selective and tunable detection of cysteine and glutathione
Chem. Commun., 2013, 49, 771
26. K.-H. Leung, H.-Z. He, W. Wang, H.-J. Zhong, D. S.-H. Chan, C.-H. Leung*, D.-L. Ma*
Label-free luminescent switch-on detection of endonuclease IV activity using a G-quadruplex-selective iridium(III) complex
ACS Appl. Mater. Interfaces, 2013, 23, 12249
25. K.-H. Leung, H.-Z. He, H. Yang, D. S.-H. Chan, C.-H. Leung*, D.-L. Ma*
A G-quadruplex-selective luminescent switch-on probe for the detection of sub-nanomolar human neutrophil elastase
RSC Adv., 2013, 3, 1656
24. K.-H. Leung, H.-Z. He, D. S.-H. Chan, W.-C. Fu, C.-H. Leung, D.-L. Ma*
An oligonucleotide-based switch-on luminescent probe for the detection of kanamycin in aqueous solution
Sensor Actuat. B-Chem., 2013, 177, 487
23. K.-H. Leung, H.-Z. He, H.-J. Zhong, L. Lu, D. S.-H. Chan, D.-L. Ma*, C.-H. Leung*
A highly sensitive G-quadruplex-based luminescent switch-on probe for the detection of polymerase 3' to 5' proofreading activity
Methods, 2013, 64, 224.
22. H.-Z. He, K.-H. Leung, H. Yang, D. S.-H. Chan, C.-H. Leung, J. Zhou, A. Bourdoncle, J.-L. Mergny, D.-L. Ma*
Label-free detection of picomolar lead(II) ions in aqueous solution using a metal-based luminescent switch-on probe
Biosens. Bioelectron., 2013, 41, 871.
21. K.-H. Leung, L. Lu, M. Wang, T.-Y. Mak, D. S.-H. Chan, F.-K. Tang, C.-H. Leung, H.-Y. Kwan, Z. Yu, D.-L. Ma*
A label-free luminescent switch-on assay for ATP using a G-quadruplex-selective iridium(III) complex
PLoS ONE, 2013, 10, e77921.
20. D.-L. Ma*, H.-Z. He, K.-H. Leung, H.-J. Zhong, D. S.-H. Chan, C.-H. Leung*
Label-free luminescent DNA oligonucleotide-based probes
Chem. Soc. Rev., 2013, 42, 3427
19. K.-H. Leung, V. P.-Y. Ma, H.-Z. He, D. S.-H. Chan, C.-H. Leung, D.-L. Ma*
A highly selective G-quadruplex-based luminescent switch-on probe for the detection of nanomolar strontium(II) ion in sea water
RSC Adv., 2012, 2, 8273
18. H.-Z. He, K.-H. Leung (Co-first author), W.-C. Fu, D. S.-H. Chan, C.-H. Leung, D.-L. Ma*
Application of a DNA-based luminescence switch-on method for the detection of mercury(II) ions in water samples of Hong Kong
Environ. Res. Lett., 2012, 7, 044032
Highlighted in
-
Environmental research web - Insight: mercury sensing by a label-free DNA-based biosensor, Feb 11, 2013
17. H.-Z. He, V. P.-Y. Ma, K.-H. Leung (Co-first author), D. S.-H. Chan, H. Yang, Z. Cheng, C.-H. Leung, D.-L. Ma*
A label-free G-quadruplex-based switch-on fluorescence assay for the selective detection of ATP
Analyst, 2012, 137, 1538
Highlighted in
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Vibhuti Patel, Deputy Editor of Analyst
16. D.-L. Ma*, H.-Z. He, V. P.-Y. Ma, D. S.-H. Chan, K.-H. Leung, H.-J. Zhong, L.-H. Lu, J.-L. Mergny, C.-H. Leung
Label-free sensing of pH and silver nanoparticles using an "OR" logic gate
Anal. Chim. Acta, 2012, 733, 78
15. D.-L. Ma*, V. P.-Y. Ma, D. S.-H. Chan, H.-Z. He, K.-H. Leung, C.-H. Leung*
Recent advances in luminescent metal complexes for sensing
Coord. Chem. Rev., 2012, 256, 3087
Bioactive transition‐metal complexes for biomedical applications
b. Structure-based inhibitors
14. C.-H. Leung*, L.-J. Liu, K.-H. Leung, D.-L. Ma*
Epigenetic modulation by inorganic metal complexes
Coord. Chem. Rev., 2016, 319, 2
13. H.-J. Zhong, L. Lu, K.-H. Leung, C. C. L. Wong, C. Peng, S.-C. Yan, D.-L. Ma, * Z. Cai*, H.-M. D.Wang*, C. H. Leung*
An iridium(III) based irreversible protein–protein interaction inhibitor of BRD4 as a potent anticancer agent
Chem. Sci., 2015, 6, 5400
12. K.-H. Leung, L.-J. Liu, S. Lin, L. Lu, H.-J. Zhong, D. Susanti, W. Rao, M. Wang, W.-I. Che, D. S.-H. Chan, C.-H. Leung*, P. W.-H. Chan*, D.-L. Ma*
Discovery of a Small-Molecule Inhibitor of STAT3 by Ligand-Based Pharmacophore Screening
Methods, 2015, 71, 38
11. H.-J. Zhong, K.-H. Leung (Co-first author), S. Lin, D. S.-H. Chan, Q.-B. Han, S. L.-F. Chan, D.-L. Ma*, C.-H. Leung*
Discovery of Deoxyvasicinone Derivatives as Inhibitors of NEDD8-Activating Enzyme
Methods, 2015, 71, 71
10. L.-J. Liu, K.-H. Leung, S. Lin, D. S.-H. Chan, D. Susanti, W. Rao, P. W. H. Chan, D.-L. Ma*, C.-H. Leung*
Pharmacophore modeling for the identification of small-molecule inhibitors of TACE
Methods, 2015, 71, 92
9. D.-L. Ma*, L.-J. Liu, K.-H. Leung, Y.-T. Chen, H.-J. Zhong, D. S.-H. Chan, H.-M. D. Wang*, C.-H. Leung*
Antagonising STAT3 dimerization by a rhodium(III) complex
Angew. Chem. Int. Ed., 2014, 53, 9178
8. L.-J. Liu, K.-H. Leung (Co-first author), D. S.-H. Chan, D.-L. Ma*, C.-H. Leung*
Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening
Cell Death Dis., 2014, 5, e1293.
7. H.-J. Zhong, K.-H. Leung (Co-first author), L.-J. Liu, L. Lu, D. S.-H. Chan, C.-H. Leung*, D.-L. Ma*
“Antagonism of mTOR Activity by a kinetically inert rhodium(III) complex
ChemPlusChem, 2014, 79, 508
6. H. Yang, H.-J. Zhong, K.-H. Leung (Co-first author), D. S.-H. Chan, V. P.-Y. Ma, R. Nanjunda, W. D. Wilson, D.-L. Ma*, C.-H. Leung*
Structure-Based Design of Flavone Derivatives as c-myc Oncogene Down-Regulators
Eur. J. Pharm. Sci., 2013, 48, 130
5. D.-L. Ma*, V. P.-Y. Ma, D. S.-H. Chan, K.-H. Leung, H.-Z. He, C.-H. Leung*
Bioactive luminescent transition‐metal complexes for biomedical applications
Angew. Chem., Int. Ed., 2013, 52, 7666
4. H.-J. Zhong, V. P.-Y. Ma, Z. Cheng, D. S.-H. Chan, H.-Z. He, K.-H. Leung, D.-L. Ma*, C.-H. Leung*
Discovery of a Natural Product Inhibitor Targeting Protein Neddylation by Structure-Based Virtual Screening
Biochimie, 2012, 94, 2457
3. D.-L. Ma*, D. S.-H. Chan, V. P.-Y. Ma, K.-H. Leung, H.-J. Zhong, C.-H. Leung*
Current advancements in Ab luminescent probes and inhibitors of Ab aggregation
Curr. Alzheimer Res., 2012, 9, 830.
2. D.-L. Ma*, V. P.-Y. Ma, D. S.-H. Chan, K.-H. Leung, H.-J. Zhong, C.-H. Leung*
In silico screening of quadruplex-binding ligands
Methods, 2012, 57, 106
1. D.-L. Ma*, V. P.-Y. Ma, D. S.-H. Chan, H.-Z. He, K.-H. Leung, C.-H. Leung*
Recent advances in luminescent metal complexes for sensing
Coord. Chem. Rev., 2012, 256, 3087