top of page

Research

Our research program, which spans the disciplines of bioanalytical chemistry and chemical biology, focuses on developing imaging tools for organelle chemotype profiling and utilizing these in-house developed tools to understand biological processes and therapeutic potentials. We aim to develop a comprehensive suite of imaging tools to fingerprint or profile the intricate details of cellular components at the subcellular level. These tools leverage cutting-edge technologies such as nanomaterials, functional molecules, multi-spectral imaging, to map and quantify various cellular components such as ions and chemicals. By enabling precise localization and chemical assessment of subcellular entities, these tools will deepen our understanding of complex cellular processes such as ion physiology and ion channel function, contributing to the development of ion channel-targeted therapies.

Subcellular Imaging Tools for Organelle Chemotype Fingerprinting

Research statement (5).png

Immunity and Diseases  

Chloride Homeostasis Regulates cGAS-STING Signaling

The cGAS–STING signaling pathway has emerged as a key mediator of inflammation. However, the roles of chloride homeostasis on this pathway are unclear. We uncovered a correlation between chloride homeostasis and cGAS-STING signaling. We found that dysregulation of chloride homeostasis attenuates cGAS-STING signaling. It reveals that chloride homeostasis majorly affects cGAS-STING pathway and suggest a provocative strategy to dampen STING-mediated inflammation via targeting chloride channels.

DOI:10.1101/2024.04.08.588475

image.png

Bioactive transition metal complexes for biomedical applications​

G-quadruplex recognition for DNA nanosensor

c4sc03319a-f1_hi-res.gif
G4 Ir.gif

Structure-based inhibitors

41419_2014_Article_BFcddis2014250_Fig4_HTML.webp

Chemical imaging

image.png

Acknowledgement:

Website-Events-Calendar-Logo-Clarkson.jpg
nia-nih.png

© KLeung Research Group

bottom of page