Research
Ka Ho Leung Group at Clarkson University is an interdisciplinary research team. Using the principles and techniques of Nanotechnology, Chemical Biology, and Bioanalytical Chemistry. Our focus revolves around the design of innovative imaging tools capable of quantifying chemicals chloride and related chemicals within different specific cellular organelles. We seek to provide a panel of imaging tools for the study of chloride physiology and chloride homeostasis. Use of these tools will propel our understanding of chloride’s physiological functions and enable future research for chloride channel-targeted therapy.
1. Functional Fluorophores for Live Cell Imaging
2. Quantitative Reporters for Subcellular Imaging Toolbox
3. Chloride Physiology
The cGAS–STING signaling pathway has emerged as a key mediator of inflammation. However, the roles of chloride homeostasis on this pathway are unclear. We uncovered a correlation between chloride homeostasis and cGAS-STING signaling. We found that dysregulation of chloride homeostasis attenuates cGAS-STING signaling in a lysosome-independent manner. It reveals that chloride homeostasis majorly affects cGAS-STING pathway and suggest a provocative strategy to dampen STING-mediated inflammation via targeting chloride channels.
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